2022 NFL Kickoff Game Picks: Rams vs. Bills

Los Angeles Rams have the NFL's worst schedule based on opponent winning percentage, which could hinder a Super Bowl push.

Thursday's NFL Kickoff Game pits them against the Buffalo Bills.

Caesars Sportsbook has Buffalo as the 2023 Super Bowl favorite. Josh Allen, Stefon Diggs, and Devin Singletary return.

The Rams boast QB Matthew Stafford, WR Cooper Kupp, and RB Cam Akers.

8:20 p.m. is game time. at SoFi Stadium. ET. Caesars Sportsbook has Buffalo as a 2.5-point favorite and a 52-point over/under.

Since its debut, the model has made $100 participants over $7,500 on top-rated NFL picks.

As of the 2022 NFL season, the model's top-rated picks have won 138 of the last 97 games since the 2017 season.

The algorithm has also beaten 94% of CBS Sports Football Pick'em players four times in the last six years.

Now, the algorithm has simulated Bills vs. Rams in NFL Kickoff Game 2022 10,000 times and published its predictions.